Cellular Longevity & Mitochondrial Axis
Telomeric Chromatin Architecture & Mitochondrial-Derived Bioenergetics
Investigative profiles of synthetic tetrapeptides and mitochondrial open reading frame-derived peptides analyzed for telomerase catalytic subunit (hTERT) activation, cardiolipin preservation, and cellular ROS mitigation.
Reagents in this Signaling Category
Epithalon
Synthetic Pineal Tetrapeptide (Ala-Glu-Asp-Gly)
Epithalon (Epitalon) is a synthetic tetrapeptide modeled on the endogenous pineal extract epithalamin. Studied extensively in biogerontology laboratories for its ability to overcome the Hayflick limit via telomerase catalytic subunit (hTERT) transcription and chromatin remodeling.
MOTS-c
Mitochondrial Open Reading Frame of the 12S rRNA-c (16-AA Peptide)
MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA locus. Investigated in metabolic biology laboratories for its regulation of the folate-methionine cycle, direct activation of AMPK, and restoration of metabolic plasticity.